An early role for Danes was that of Angela Chase in the 1994 television drama series, My So-Called Life, for which she won a Golden Globe Award and received an Emmy nomination. She played Elizabeth ("Beth") March in the 1994 movie adaption of Little Women. She also appeared as Holly Hunter's daughter in Home for the Holidays, which was directed by Jodie Foster. This was followed by her role as Juliet Capulet in Baz Luhrmann's 1996 film William Shakespeare's Romeo + Juliet, co-starring Leonardo DiCaprio. Later that year she turned down the lead role of Rose DeWitt Bukater in Titanic because she had been exhausted by working on Romeo + Juliet. In 1999, she made her first appearance in an animated feature with the English version of Princess Mononoke, and took the lead role in Brokedown Palace, alongside Kate Beckinsale and Bill Pullman.
In 2002, Danes starred opposite Susan Sarandon and Kieran Culkin in Igby Goes Down. She later co-starred as Meryl Streep's daughter in the Oscar-nominated, The Hours, with Nicole Kidman, Julianne Moore, and Ed Harris. The following year, she was cast in Terminator 3: Rise of the Machines, followed by Stage Beauty in 2004. She earned critical acclaim in 2005 when she starred in Steve Martin's Shopgirl alongside Martin and Jason Schwartzman, and in The Family Stone opposite Sarah Jessica Parker and Diane Keaton. In 2007, Danes appeared in the fantasy epic Stardust, which she described as a "classic model of romantic comedy", opposite Charlie Cox, Michelle Pfeiffer, Robert De Niro, and Sienna Miller, and will appear in The Flock, opposite Richard Gere.
Danes appeared in Off-Broadway plays including Happiness, Punk Ballet, and Kids On Stage, in which she choreographed her own solo dance. She also wrote the introduction to Neil Gaiman's Death: The Time of Your Life. Danes auditioned for the role of Lois Lane in Superman Returns before the role went to Kate Bosworth.
In March 2007, Danes appeared with Patrick Wilson in a television commercial for Gap in which the pair dances to the song "Anything You Can Do" from the musical Annie Get Your Gun. Danes has recently appeared onstage at Manhattan's PS122, an avant-garde performance space, in a series of dance pieces by choreographer Tamar Rogoff. Danes made her stage debut at PS122 as a child.
On October 19, 2007, Danes made her Broadway debut in the revival of George Bernard Shaw's Pygmalion, starring as Eliza Doolittle.
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