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In 1997, she was cast as the smart but troubled Meadow Soprano, daughter of New Jersey mob boss Tony Soprano. The show premiered in 1999 and became a success, with Sigler rising to some fame as a TV actress. During the early production of The Sopranos, Sigler struggled with an eating disorder and is now a spokesperson for the National Eating Disorders Association. Sigler appeared in a CNN special with Paula Zahn in which she, jockey Shane Sellers, actress Jane Fonda, and two others revealed their struggles with eating disorders.
In 2000, while filming Campfire Stories in Hamburg, New Jersey, Sigler was paralyzed from the waist down for several days having contracted Lyme disease.
Sigler then spent five months on Broadway from October 2002 through February 2003 playing Belle in Beauty and the Beast where she replaced long-running Belle Sarah Litzsinger. She has continued to appear in theatrical roles, such as Rodgers and Hammerstein's Cinderella.
In 2004, she starred as "Hollywood Madam" Heidi Fleiss in the USA television movie Call Me: The Rise and Fall of Heidi Fleiss. In that same year, she had her first starring feature film role, Extreme Dating, an independent film.
In 2005 Sigler starred in Lovewrecked, and in Mariah Carey's "Through the Rain" music video.
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